- Chris Hemsworth as Thor
- Vanessa Kirby as Sue Storm
- Anthony Mackie as Captain America
- Sebastian Stan as Bucky Barnes
- Letitia Wright as Black Panther
- Paul Rudd as Ant-Man
- Wyatt Russell as U.S Agent
- Tenoch Huerta Mejia as Namor
- Ebon Moss-Bachrach as The Thing
- Simu Liu as Shang-Chi
- Florence Pugh as Yelena Belova
- Kelsey Grammer as Beast
- Lewis Pullman as Sentry
- Danny Ramirez as Falcon
- Joseph Quinn as Johnny Storm
- David Harbour as Red Guardian
- Winston Duke as M'Baku
- Hannah John-Kamen as Ghost
- Tom Hiddleston as Loki
- Patrick Stewart as Professor X
- Ian McKellen as Magneto
- Alan Cumming as Nightcrawler
- Rebecca Romijn as Mystique
- James Marsden as Cyclops
- Channing Tatum as Gambit
- Pedro Pascal as Reed Richards
- Robert Downey Jr. as Doctor Doom